Table 2.
Extent of bacterial killing exerted by 5-chloro-2-hydroxy-N-[(2S)-3-methyl-1-oxo-1-{[4-(trifluoromethyl)-phenyl]amino}butan-2-yl]benzamide (1f), N-{(2S)-1-[(4-bromophenyl)amino]-3-methyl-1-oxobutan-2-yl}-4-chloro-2-hydroxybenzamide (1g), and 4-chloro-N-{(2S)-1-[(3,4-dichlorophenyl)amino]-3-methyl-1-oxobutan-2-yl}-2-hydroxybenzamide (1h) over time against four staphylococci strains.
| Drug and concentration (multiplicity of MIC) | Number of strains showing the following log10 CFU/mL decreasea at the designated incubation time | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 h | 6 h | 8 h | 24 h | |||||||||
| −1 | −2 | −3 | −1 | −2 | −3 | −1 | −2 | −3 | −1 | −2 | −3 | |
| Comp. 1f | ||||||||||||
| 4× MIC | 2 | 1 | 1 | 4 | 3 | 2 | 4 | 4 | 2 | 4 | 4 | 4 |
| 2× MIC | 1 | 1 | 1 | 1 | 1 | 1 | 3 | 1 | 1 | 4 | 3 | 0 |
| 1× MIC | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Comp. 1g | ||||||||||||
| 4× MIC | 2 | 1 | 1 | 2 | 1 | 1 | 4 | 2 | 1 | 4 | 4 | 2 |
| 2× MIC | 1 | 1 | 0 | 1 | 1 | 1 | 2 | 1 | 1 | 0 | 0 | 0 |
| 1× MIC | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Comp. 1h | ||||||||||||
| 4× MIC | 2 | 2 | 0 | 4 | 2 | 2 | 4 | 3 | 2 | 4 | 4 | 2 |
| 2× MIC | 1 | 0 | 0 | 2 | 1 | 0 | 2 | 0 | 0 | 1 | 0 | 0 |
| 1× MIC | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
CFU: colony-forming units.
aΔ(log10 CFU/mL) values of −1, −2, and − 3 log10 CFU/mL correspond to 90% (bacteriostatic), 99% (bacteriostatic), and 99.9% (bactericidal) of killing, respectively.