Glucose Deprivation in hypoxia does not enhance ODD-luc degradation, or decrease global transcription, translation, or luciferase activity A. ODD-luc activity after 2h hypoxia or OGD in the presence of lysosomal inhibitors NH4Cl 5mM or leupeptin 250uM. B. ODD-luc activity after 2h pre-treatment with hypoxia followed by 0, 15, 30, 45, or 60 min treatment with Cyclohexamide (10ug/mL) in hypoxia with 20mM glucose (CHX) or 0mM glucose (CHX + GD); C. CMV-luc activity after 2h normoxia or hypoxia with glucose concentrations from 0–20mM; D. ODD-luc activity after 2h hypoxia and co-treatment with actinomycin D at 0.25–8ug/mL. ***p<.001, in ANOVA with posthoc Tukey test.