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. Author manuscript; available in PMC: 2015 Feb 9.
Published in final edited form as: Stem Cells. 2014 Jun;32(6):1437–1450. doi: 10.1002/stem.1707

Figure 7. YB-1 transgenic mice form hormone-receptor negative tumors.

Figure 7

(a) qRT-PCR analysis of hYB-1 mRNA transcript in wild-type (WT) and TG2 YB-1 transgenic mice normalized to 488 WT. (b) Gene expression analysis of YB-1 transgenic TG2 mice (n = 4) relative to the WT controls (n = 3) using the NanoString nCounter platform (red, high expression; green, low expression). (c) Depiction of the genetic and phenotypic features that define each step of YB-1-driven transformation of HMECs into a TNBC. The epigenetic alterations following YB-1 induction in the HTRY cells are shown in detail.