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. 2014 Oct 31;21(1):157–165. doi: 10.1089/ten.teb.2014.0383

FIG. 1.

FIG. 1.

Micromechanical loading in cardiomyocytes (CMs). (a) The intrinsic load as a result of the contractile activity, (b) an extrinsic load may be applied to stimulate a preload. (c) The microenvironment influences the after-load of tension that is generated in cells in vitro; it can be controlled by surface chemistry, stiffness, topography, and 3D architecture of scaffolds.