Table 3.

Covert HE and development of outcomes

Time to outcome	CHE diagnosis HR (95% CI) (P value)	MELD Score HR (95% CI) (P value)
First OHE episode	2.1 (1.01–4.5) (P=0.05)	1.15 (1.03–1.27) (P=0.01)
First hospitalization	2.5 (1.4–4.5) (P=0.002)	1.17 (1.1–1.3) (P ≤ 0.0001)
Death	4.9 (1.03–23.8) (P=0.04)	1.18 (1.03–1.35) (P=0.015)
Death/transplant	3.4 (1.2–9.7) (P=0.01)	1.18 (1.1–1.3) (P=0.0004)

CHE, covert hepatic encephalopathy; CI, confidence interval; HE, hepatic encephalopathy; HR, hazard ratio; MELD, model for end-stage liver disease; OHE, overt hepatic encephalopathy.

Models were adjusted for gender, age, and etiology of cirrhosis.