Table 3.
Parameters | VH1 (n = 5) | CsA1 (n = 5) | VH4 (n = 5) | CsA4 (n = 5) |
---|---|---|---|---|
Body weight, g | 215±6 | 225±4 | 300±4 | 245±5* |
Water intake, ml/24 h | 14±2 | 17±3 | 15±1 | 34±6* |
Blood pressure, mm Hg | 125±4 | 128±5 | 122±3 | 124±3 |
Urine osmolality, mosm/kg | 1,212±430 | 1,112±230 | 1,139±264 | 560±28* |
FENa, % | 0.03±0.01 | 0.02±0.01 | 0.03±0.01 | 0.04±0.01 |
TcW, ml/24 h | 48±4 | 41±7 | 43±3 | 25±3* |
BUN, mg/dl | 8.0±0.6 | 18.5±22.1* | 10.0±0.9 | 33.0±2.0* |
SCr, mg/dl | 0.56±0.02 | 0.62±0.02 | 0.58±0.02 | 1.90±0.08* |
TIF, % | 0.0±0.0 | 3.2±1.4 | 0.0±0.0 | 28.5±3.0* |
Values are means ± SEM. n = Number of rats. VH = Vehicle-treated group; CsA = cyclosporine A; FENa = fractional excretion of sodium; TcW = free-water reabsorption; BUN = blood urea nitrogen; SCr = serum creatinine; TIF = tubulointerstitial fibrosis.
p < 0.05 vs. VH.