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. Author manuscript; available in PMC: 2015 Feb 9.
Published in final edited form as: Prog Brain Res. 1999;120:119–132. doi: 10.1016/s0079-6123(08)63550-5

TABLE 2.

Effects of 3′,5′-bisphosphate derivatives on stimulation of PLC in turkey erythrocytes and inhibition of effects of 10 nM 2-MeSATP

graphic file with name nihms-657579-t0008.jpg
Compound R1 R2 R3 R4 Agonist
Effect
(% maximum)		 EC50
(μM)		 Antagonist
Effect
(%maximum)		 IC50
(μM)
1 H NH2 H OH 21% 1.28 77% 4.19
2 H NH2 H OCH3 35% 12.9 65% 12.4
3 H NH2 H H 12% 6.26 87% 5.76
4 Cl NH2 H H 19% 0.651 80% 2.01
5 SCH3 NH2 H H 22% 0.550 77% 2.11
6 H NH2 Br H 0% 100% 36.7
7 H NHCH3 H H 0% 99% 0.330
(MRS 219)
8 H NHCH2CH3 H H 0% 100% 1.08
9 H NH(CH2)2CH3 H H 0% <20%
10 H NHCOC6H6 H H 0% 0%
11 H N(CH3)2 H H 0% 70% 46.7
12 H Cl H H <10% <10%
13 H OH H H 0% <20%
14 H SCH3 H H 0% 78% 29.1