Figure 2. Concepts identified using the MS Ontology in the competency questions.

Figure shows the concepts (in grey boxes) retrieved in the competency questions (search strategy) annotated by the MS Ontology and linked to other MS Ontology concepts, indicating the PMID of the abstract from PubMed and the type of interaction described in such abstract. A) references linking brain atrophy and CNS repair with remyelination in MS; B) references linking Myelin Oligodendrocyte Glycoprotein (MOG) to antibody-mediated demyelination; and C) references linking fingolimod tested as a drug for treatment of relapsing-remitting MS in phase 3 clinical trials