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. 2015 Feb 9;10(2):e0116718. doi: 10.1371/journal.pone.0116718

Figure 3. Drug-target-pathway map of MS drugs using MS Ontology compared to KEGG database.

Figure 3

A search in the KEGG database (a database of molecular pathways and drugs), identified pathways associated with interferon-beta and teriflunomide (box in the left). The automatic retrieval using MS Ontology identified additional pathways for all current MS disease modifying therapies, including mitoxantrone, natalizumab, azathioprine, laquinimod, simvastatin, levostatin, dimethyl-fumarate, rituximab and daclizumab and their interactions.