Figure 4.

Structural Features of Listerin Bound to the 60S-RNC

(A) View of the exit tunnel side of the 60S ribosomal subunit depicting EM density filtered to 5 Å at a threshold that displays secondary structure. The density for Listerin is orange and fit with structural models of HEAT repeats, the RWD domain, and the RING domain. Models for the following ribosomal protein are also fit in position: eL22 (dark blue), eL31 (light blue), uL23 (gray), and uL29 (gray). The exit tunnel is shown as a dashed circle.

(B) Atomic model of Listerin’s RWD domain with the neighboring ribosomal proteins eL22 (dark blue) and eL31 (light blue), depicting possible sites of interaction (arrows).

See also Figure S4.