Figure 1. IL-1R deficiency results in enhanced chlamydial colonization while the deficiency of its antagonist IL-Ra reduces bacterial colonization and augments infection clearance during genital C. muridarum infection.
C. muridarum infection course in (A), WT (N=5) and IL-1R KO (N=5), and (C), WT (N=5) and IL-1Ra KO (N=5) mice. Log10 (IFUs/ml) were calculated from genital swabs as described in Methods and graphed as means ± standard error of the means of animals positive for infection on that day. Significance was determined by two-way RM ANOVA (WT vs. IL-1R KO: p = 0.039; WT vs. IL-Ra KO: p = 0.015 (A). Percent of mice that remain infected in each group are indicated in (B) and (D). P = 0.0737 for WT vs. IL-1R KO (B) and p = 0.0311 for WT vs. IL-1Ra KO (D) by Kaplan-Meier survival analysis. A representative of 4 experiments for (A) and (B) and of 2 experiments for (C) and (D) is shown.