Skip to main content
. Author manuscript; available in PMC: 2015 Feb 10.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2007 Jul 26;27(10):2068–2078. doi: 10.1161/01.ATV.0000282199.66398.8c

TABLE 1.

Examples of Existing Case-Control Studies to Identify PAD Susceptibility Genes

Gene HUGO Name Polymorphism (as Described) Case Subjects, No. Control Subjects, No. Ethnicity (as Described) Odds Ratio P Reference
Angiotensin-converting enzyme ACE Insertion/deletion 98 240 German NS 140
Angiotensin-converting enzyme ACE Insertion/deletion 45 316 Chinese NS 141
Angiotensin-converting enzyme ACE Insertion/deletion 522 522 White, Austrian NS 142
Chemokine, CC motif, receptor 5 CCR5 Δ32 76 172 Italian NS 143
Chemokine, CX3C motif, receptor 1 CX3CR1 V249I, T280 mol/L 522 522 White, Austrian NS 144
Cytochrome B α subunit (p22 phox) CYBA C242T 324 295 Austrian NS 145
Factor II F2 G20210A 336 300 Austrian NS 146
Factor II F2 G20210A 184 330 White, French 4.3 0.02 147
Factor II F2 G20210A 433 433 Austrian NS 148
Factor V F5 G1691A (Leiden) 336 300 Austrian NS 146
Factor V F5 G1691A (Leiden) 184 330 White, French NS 147
Factor V F5 G1691A (Leiden) 433 433 Austrian NS 148
Factor VII F7 R353Q 88 423 Scottish NS 149
Factor XIII, A subunit F13A1 V34L 873 523 Austrian NS 150
Fibrinogen FGB G-455A 88 423 Scottish NS 149
Fibrinogen FGB T1689G 104 663 Scottish NS 151
Fibrinogen FGB Bcl I digestion 121 126 Scottish 7.6 0.03 152
Haptoglobin HP Hp1, Hp2 141 1000 White, Belgian 1.82 <0.001 153
Hemochromatosis HFE C282Y, H63D 522 522 White, Austrian NS 154
Hepatic lipase LIPC G-250A 241 241 White, Austrian 1.69 0.02 155
Intracellular adhesion molecule 1 ICAM1 K469E 75 227 White, Italian 3.5 0.004 156
Integrin β3 (platelet glycoprotein IIIa) ITGB3 PLA1/A2 815 518 Austrian NS 157
Integrin β3 (platelet glycoprotein IIIa) ITGB3 P1A 104 663 Scottish 0.49 <0.05 151
Interleukin 6 IL6 G-174C 84 183 White, Italian 4.6 0.001 158
Methylenetetrahydrofolate reductase MTHFR C677T 51 51 Swiss NS 159
Methylenetetrahydrofolate reductase MTHFR C677T 433 433 Austrian NS 148
Plasminogen activator inhibitor 1 PAI1 HindIII 88 423 Scottish NS 149
Purinergic receptor P2Y P2RY12 H2 haplotype 184 330 White, French 2.3 0.002 160

NS indicates not specified.