Skip to main content
. Author manuscript; available in PMC: 2015 Feb 10.
Published in final edited form as: Lancet. 2004 Nov 13;364(9447):1779–1785. doi: 10.1016/S0140-6736(04)17401-1

Figure 1. Proposed mechanism of cryopyrin function.

Figure 1

Cryopyrin interacts with ASC resulting in activation of caspase 1 or NF-κB, leading to the release of proinflammatory cytokines. Pyrin inhibits the interaction between cryopyrin and ASC. IL-1Ra competes with interleukin 1, for its receptor. Activation of interleukin-1 receptor also leads to NF-κB activation. Interleukin 6 is released into the blood, leading to fever and arthralgia.