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. 2015 Feb 9;212(2):267–280. doi: 10.1084/jem.20140508

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© 2015 Liu et al.

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Figure 4. — Moesin, and not MLC, is essential for cell orientation. (A) Control HL60 cells (Ctrl; top), moesin RNAi–treated cells (middle), or Y27632-treated cells (bottom) migrated toward a point source of 10 µM fMLF. (B and C) Cells were treated as in A, and CI (B) and migration speed (C) were calculated. **, P < 0.01; ***, P < 0.001 compared with control (Student’s t test). (D) Control and moesin RNAi cells were exposed to a 10-nM IL-8 gradient, and CI was calculated. ***, P < 0.01 (Student’s t test). (E) Control (top) and moesin RNAi–treated (bottom) cells (n > 30 per group) were exposed to C. albicans. (A and E) Bars, 10 µm. Data are representative of (A and E) or are compiled from three independent experiments (B–D; mean and SEM in B–D).