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. 2015 Feb 9;11(2):e1004044. doi: 10.1371/journal.pcbi.1004044

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© 2015 Lee et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Inline graphic — (a) Configurations of the DRY motif and ionic-lock in the three receptor states. (b) The distances of R102_{C_ζ}-E228_{C_δ} (left, top) and L110_{C_α}-A221_{C_α} (left, bottom) are colored in black, blue, and red for the apo, antagonist-bound, and agonist-bound states, respectively, and their histograms are shown on the right side of the plots. On the right panel, scattered plot using the distances of R102-E228 and L110-A221 is shown with the yellow arrow depicting the conformational transition between three ligand forms. (c) Diagram of the H-bond network in the three receptor states.

Inline graphic — (a) Configurations of the DRY motif and ionic-lock in the three receptor states. (b) The distances of R102_{C_ζ}-E228_{C_δ} (left, top) and L110_{C_α}-A221_{C_α} (left, bottom) are colored in black, blue, and red for the apo, antagonist-bound, and agonist-bound states, respectively, and their histograms are shown on the right side of the plots. On the right panel, scattered plot using the distances of R102-E228 and L110-A221 is shown with the yellow arrow depicting the conformational transition between three ligand forms. (c) Diagram of the H-bond network in the three receptor states.