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. 2015 Feb 9;11(2):e1004044. doi: 10.1371/journal.pcbi.1004044

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© 2015 Lee et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Inline graphic — Rotameric states of (a) W129, (b) Y197, (c) CWxP motif, and (d) NPxxY motif are compared for the apo (white), antagonist-bound (cyan), and agonist-bound (pink) forms. (e) Helix bending in TM7. The helix bending angle (bendix) of TM7 was calculated using bendix program [45]. The helix is displayed as a cylinder marked with the heatmap ranging from 0^o to 20^o. The scatter plot on right side depicts the relationship between H-bond of N280-S281 and the bending angle of the TM7 helix (apo: black, antagonist-bound: blue, agonist-bound states: red). The average bending angles are annotated with the symbols, X.

Inline graphic — Rotameric states of (a) W129, (b) Y197, (c) CWxP motif, and (d) NPxxY motif are compared for the apo (white), antagonist-bound (cyan), and agonist-bound (pink) forms. (e) Helix bending in TM7. The helix bending angle (bendix) of TM7 was calculated using bendix program [45]. The helix is displayed as a cylinder marked with the heatmap ranging from 0^o to 20^o. The scatter plot on right side depicts the relationship between H-bond of N280-S281 and the bending angle of the TM7 helix (apo: black, antagonist-bound: blue, agonist-bound states: red). The average bending angles are annotated with the symbols, X.