Fig. 8.

Paroxetine interacts with ANT and VDAC of mitochondria. Rat brain mitochondria were extracted and loaded onto either the paroxetine-sepharose or Tris-sepharose columns. (a) The anti-ANT immunoreactive protein bands showed a depletion of ANT protein in the paroxetine-sepharose flow through lane and concentration of ANT protein in the paroxetine-sepharose bound fraction. (b) Similarly, there was a partial depletion of VDAC protein from the paroxetine-sepharose column and elution from the paroxetine-sepharose beads