Fig. 3.

2-Amino-6-trifluoromethylthio-benzothiazole (SKA-19) shows efficacy in multiple seizure models. (a) 6-Hz seizure test in mice: ED₅₀ 12.19 mg/kg [95 % confidence interval (CI) 8.2–17.45, n = 8 per dose]. See Fig. 2 for mouse TD₅₀ 2 h after intraperitoneal (i.p.) application. (b) Hippocampal kindled rats: ED₅₀ 5.47 mg/kg (95 % CI 2.92–8.92, n = 8 per dose). (c) Frings audiogenic seizure (AGS)-susceptible mouse model: ED₅₀ 2.15 mg/kg (95 % CI 1.52–2.65, n = 8 per dose). In all cases, testing was performed 2 h after i.p. application of SKA-19