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Space-filling diagram depicting the retromer chaperone R55 docked at its interface pocket between vacuolar protein sorting (Vps)29 (in orange) and Vps35 (in gray). R55 is predicted to make interactions with side chains from both proteins (multicolored surfaces). R55 has the systematic chemical name thiophene-2,5-diylbis(methylene) dicarbamimidothioate dihydrochloride. Binding studies using microscale thermophoresis established its Kd for the retromer core complex to be about 5 μM [19]
