Table 3.

Sensitivity and specificity of individual studies for urine IL-18 to predict AKI

Study	Time of obtaining specimen	TP	FP	FN	TN	Cutoff value (pg/ml)	Sensitivity (%)	Specificity (%)	AUROC (95 % CI)	Assess time (h)
Zheng et al. [6]	0, 4, 6, 12, and 24 h after the initiation of CPB	28	11	1	18	49	96.60	62.10	0.835 (0.729–0.940)	4
Sirota1 et al. [7]	24 h after orthotopic liver transplantation	5	7	2	26	/	72	79	0.749	24
Li et al. [11]	48 h admitted	7	4	4	47	1,800a	64	92	0.72 (0.52–0.93)	48
Chen et al. [12]	Admission	22	17	22	90	70	50	84	0.621 (0.504–0.738)	48
Parikh et al. [13]	Admission	37	83	16	175	125	69	68	0.72 (0.64–0.80)	48
Parikh et al. [14]	Admission, every 6 h	32	209	28	950	60	54	82	0.74 (0.66–0.81)	48
Endre et al. [15]	Admission	50	83	97	293	36b	34	78	0.62 (0.56–0.67)	0
Liangos et al. [16]	2 h post-cardiopulmonary bypass	10	31	3	59	92	75	66	0.66 (0.49–0.83)	2
Washburn et al. [17]	2 PM each day	39	7	64	27	75	38	78	0.54 (0.31–0.77)	24
		55	10	48	24	75	53	71	0.61 (0.43 –0.78)	48
Parikh et al. [18]	Every 2 h for the first 12 h and then once every 12 h	5	1	15	34	50	25	97	0.61	4
		10	2	10	33	50	50	94	0.75	12
		12	4	8	31	20	60	89	0.73	24
Parikh et al. [19]	Days 0, 1, and 3	38	29	14	57	25	74	66	0.731	24

IL interleukin, AKI acute kidney injury, AUROC area under the receiver operating characteristic curve, CI confidence interval, CPB cardiopulmonary bypass, FN false-negative, FP false-positive, TN true-negative, TP true-positive

^apg/mg uCr

^b(pg/ml)/mmol/l Cr