Table 5.

Pooled diagnostic accuracy of IL-18 in various settings

Subgroup factors	Subgroup criteria	Reference numbers	Q value	P value	I2 (%)	Hierarchical summary OR (95 % CI)	P value for between subgroups
Age	<18 years	5	10.23	0.037	60.9	7.51 (2.99–18.88)	0.334
	≥18 years	6	15.54	0.008	67.8	4.32 (2.48–7.51)
Predictive time	≤12 h	5	18.27	0.001	78.1	8.18 (2.19–30.51)	0.037
	24 h	4	4.48	0.214	33.0	5.07 (2.58–9.96)
	48 h	5	5.04	0.283	20.7	4.95 (3.39–7.24)
Obtaining specimen	Admission	4	13.4	0.004	77.6	3.81 (2.08–6.99)	0.388
	Other times	7	10.38	0.109	42.4	7.16 (3.62–14.18)
Patients	Cardiac surgery	4	0.59	0.90	0.01	5.28 (3.593–7.762)	0.008
	Other patients	7	23.28	0.001	74.2	5.31 (2.59–10.87)

OR odds ratio, CI confidence interval