Table 1.
Details of patients with pulmonary hypertension after chemotherapy.
| Case | Age, sex | Neoplasm | Treatment for neoplasm | Period from chemotherapy to PH onset | Clinical diagnosis [cause of death] | Pathological findings | Lung specimen |
|---|---|---|---|---|---|---|---|
| 1 | 46, M | Malignant lymphoma | Surgical resection + chemotherapy |
8 years | IP | In situ thrombosis of SPA and veins | Biopsy |
| 2 | 6, F | NB | Surgical resection + AutoPBSCT (2) + high-dose chemotherapy |
7 days | IP, PVOD | In situ thrombosis of SPA and veins | Biopsy |
| 3 | 2, F | ALL | Umbilical cord blood transplant (2) + high-dose chemotherapy | 10 days | PAH, Congenital protein C deficiency |
In situ thrombosis of SPA | Biopsy |
| 4 | 2, M | RMS | Chemotherapy + Proton therapy |
During chemotherapy | Hepatic venoocclusive disease [unknown] | In situ thrombosis of SPA and veins | Autopsy |
| 5 | 5, M | Burkitt's Lymphoma |
Chemotherapy | During chemotherapy | PVOD [refractory right HF] | PVOD | Autopsy |
| 6 | 3, M | MB | Surgical resection + chemotherapy |
9 months | s/o PAH, PVOD [IP] |
IPAH, IP | Autopsy |
| 7 | 2, F | AML | Allogeneic bone marrow transplant + high-dose chemotherapy | 2 months | s/o PVOD, cGVHD [IP] | Plexogenic arteriopathy, IP | Autopsy |
ALL = acute lymphocytic leukemia; AML = acute myelogenous leukemia; AutoPBSCT = autologous peripheral blood stem cell transplantation; cGVHD = chronic graft versus host disease; F = female; HF = heart failure; IP = interstitial pneumonia; IPAH = idiopathic pulmonary arterial hypertension; M = male; MB = medulloblastoma; NB = neuroblastoma; PAH = pulmonary arterial hypertension; PH = pulmonary hypertension; PVOD = pulmonary venoocclusive disease; RMS = rhabdomyosarcoma; SPA = small pulmonary arteries.