Table 2.
Patient characteristics-antihistamines
| Variable N(%) | Unmatched Characteristics | Matched Demographic Characteristics (1:1 propensity-scored matching) | ||||
|---|---|---|---|---|---|---|
| Variable N(%) | Incident Antihistamine Use | No Antihistamine Use | P value | Incident Antihistamine Use | No Antihistamine Use | P value |
| n = 30031 | n = 1777373 | n = 30029 | n = 30029 | |||
| Age Groups | ||||||
| 65-74 | 14853 (49.5%) | 805052 (45.3%) | <0.001 | 14851 (49.5%) | 14848 (49.5%) | 0.993 |
| 75-84 | 12728 (42.4%) | 815731 (45.9%) | 12728 (42.4%) | 12738 (42.4%) | ||
| 85+ | 2450 (8.2%) | 156590 (8.8%) | 2450 (8.1%) | 2443 (8.1%) | ||
| Gender (female) | 740 (2.5%) | 28386 (1.6%) | <0.001 | 738 (2.5%) | 722 (2.4%) | 0.672 |
| Race/Ethnicity | ||||||
| White | 21392 (71.2%) | 1171262 (65.9%) | <0.001 | 21392 (71.2%) | 21408 (71.3%) | 0.995 |
| Black | 3197 (10.7%) | 109686 (6.2%) | 3195 (10.6%) | 3196 (10.6%) | ||
| Hispanic | 1677 (5.6%) | 54610 (3.1%) | 1677 (5.6%) | 1655 (5.5%) | ||
| Other | 482 (1.6%) | 22347 (1.3%) | 482 (1.6%) | 476 (1.6%) | ||
| Unknown/missing | 3283 (10.9%) | 419468 (23.6%) | 3283 (10.9%) | 3294 (11%) | ||
| Poverty Status | ||||||
| Under the poverty limit | 23780 (79.2%) | 1035894 (58.3%) | <0.001 | 23778 (79.2%) | 23790 (79.2%) | 0.602 |
| Number of Medications | ||||||
| 0-5 | 7451 (24.8%) | 871449 (49%) | <0.001 | 7451 (24.8%) | 7447(24.8%) | 1.000 |
| 6-8 | 7045 (23.5%) | 458910 (25.8%) | 7045 (23.5%) | 7049 (23.5%) | ||
| 9-11 | 6292 (21%) | 248537 (14%) | 6292 (21%) | 6301 (21%) | ||
| >12 | 9243 (30.8%) | 198477 (11.2%) | 9241 (30.8%) | 9232 (30.7%) | ||
| Number of Physical Comorbidities | ||||||
| 0-1 | 5174 (17.2%) | 844104 (47.5%) | <0.001 | 5174 (17.2%) | 5160 (17.2%) | 0.997 |
| 2-3 | 12485 (41.6%) | 328371 (18.5%) | 12485 (41.6%) | 12497 (41.6%) | ||
| 4-5 | 8114 (27%) | 96228 (5.4%) | 8113 (27%) | 8127 (27.1%) | ||
| 6+ | 4258 (14.2%) | 508670 (28.6% | 4257 (14.2%) | 4245 (14.1%) | ||
| Number of Psychiatric Comorbidities | ||||||
| 0 | 23260 (77.5%) | 1554672 (87.5%) | <0.001 | 23260 (77.5%) | 23263 (77.5%) | 0.958 |
| 1 | 4906 (16.3%) | 178882 (10.1%) | 4906 (16.3%) | 4919 (16.4%) | ||
| 2+ | 1865 (6.2%) | 43819 (2.4%) | 1863 (6.2%) | 1847 (6.2%) | ||
| ED visits in 2005 | 10345 (34.5%) | 241958 (13.6%) | <0.001 | 10343 (34.4%) | 10343 (34.4%) | 1.000 |
| Hospital admissions in 2005 | 4472 (14.9%) | 94854 (5.3%) | <0.001 | 4471 (14.9%) | 4456 (14.8%) | 0.863 |
| Geriatric visits in 2005 | 867 (2.9%) | 42236 (2.4%) | <0.001 | 867 (2.9%) | 847 (2.8%) | 0.624 |
| Primary Care visits | ||||||
| 0-1 | 3975 (13.2%) | 478627 (26.9%) | <0.001 | 3975 (13.2%) | 3969 (13.2%) | 0.997 |
| 2-4 | 15017 (50%) | 991222 (55.8%) | 15016 (50%) | 15018 (50%) | ||
| 5+ | 11039 (36.8%) | 307524 (17.3%) | 11038 (36.8%) | 11042 (36.8%) | ||
| Outcomes | ||||||
| Death within 1 year | 3685 (12.2%) | 77318 (4.4%) | <0.001 | 3684 (12.3%) | 2033 (6.8%) | <0.001 |
| Emergency department visit within 1 year | 13267 (44.2%) | 230839 (13%) | <0.001 | 13266 (44.2%) | 7562 (25.2%) | <0.001 |
| Hospitalization within 1 year | 5729 (19.1%) | 81389 (4.6%) | <0.001 | 5729 (19.1%) | 2895 (9.6%) | <0.001 |
| Emergency department visit for fall within 1 year | 383 (1.3%) | 6488 (0.4%) | <0.001 | 383 (1.3%) | 216 (0.7%) | <0.001 |
| Hospitalization for fall within 1 year | 109 (0.4%) | 1583 (0.1%) | <0.001 | 109 (0.4%) | 56 (0.2%) | <0.001 |
| Death emergency department visit or hospitalization within 1 year (composite) | 16142 (53.8%) | 304362 (17.1%) | <0.001 | 16141 (53.8%) | 9276 (30.9%) | <0.001 |