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. 2014 Dec 11;2:23. doi: 10.1186/2049-3002-2-23

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© Kamphorst et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The main additional AcCoA source in hypoxia is acetate. (A) Percentage ¹³C₂-acetyl-CoA labeling quantified from palmitate labeling in hypoxic (1% O₂) and normoxic MDA-MB-468 cells grown in medium with U-¹³C-glucose and U-¹³C-glutamine and additionally supplemented with indicated concentrations of U-¹³C-acetate. (B) Acetate concentrations in fresh 10% DFBS, DMEM, and DMEM with 10% DFBS. (C) Percentage ¹³C₂-acetyl-CoA labeling for hypoxic (1% O₂) HeLa and A549 cells. For (A) and (C), data are means ± SD of n ≥ 2. For (B), data are means ± SEM of n = 3.