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. 2014 Sep 30;25(2):149–158. doi: 10.1002/hipo.22359

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© 2014 The Authors. Hippocampus Published by Wiley Periodicals, Inc.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Antagonism of mGlu5 prevents the increase of decision time associated with the decrease of correct answers during extinction and renewal. Both graphs represent the amount of time that was needed to reach the end of an arm (both correct and incorrect choices) after the opening of the door. The ABA paradigm is represented in panel a and the AAA paradigm is represented in panel b. During the learning of the task, the time needed to reach the end of an arm steadily decreased while the correct answers increased, until a basal level of correct answers was reached on Day 3 that reflected animal reaching the 80% criterion of correct arm choices. Treatment with the mGlu5 antagonist, MPEP, before testing on Day 4 had no effect on decision time during extinction learning on Day 4, but it significantly reduced decision time on Day 5 compared to controls. This suggests that MPEP may elicit impaired consolidation of extinction learning on Day 4.