Table 3.
Geometric Mean Metabolite Fractions (Arithmetic Mean for %DMA) for each AS3MT Haplotype and P values from Multivariate Regression Analyses (Controls Only)a
| Controls with total urinary arsenic >5 µg/L |
|||
|---|---|---|---|
| Haplotype/haplotype combinations | %iAs (N) | %MMA (N) | %DMA (N) |
| Haplotype 1 | |||
| 0 copies | 8.2 (75) | 15.3 (68) | 72.2 (78) |
| 1/2 copies | 8.6 (194) | 16.1 (177) | 72.4 (199) |
| P valueb | 0.21 | 0.49 | 0.88 |
| Haplotype 2 | |||
| 0 copies | 8.9 (210) | 16.6 (189) | 71.3 (215) |
| 1/2 copies | 6.9 (59) | 13.5 (56) | 76.0 (62) |
| P value | 0.032 | 0.020 | 0.033 |
| Haplotype 3 | |||
| 0 copies | 8.1 (173) | 15.9 (160) | 73.1 (180) |
| 1/2 copies | 9.2 (96) | 15.7 (85) | 70.9 (97) |
| P value | 0.24 | 0.92 | 0.25 |
| Haplotype 4 | |||
| 0 copies | 8.2 (210) | 14.8 (192) | 73.9 (216) |
| 1/2 copies | 9.5 (59) | 20.5 (53) | 66.9 (61) |
| P value | 0.14 | <0.001 | <0.001 |
| Haplotype 5 | |||
| 0 copies | 8.6(234) | 16.0(215) | 72(240) |
| 1/2 copies | 7.8(35) | 14.9(30) | 74.5(37) |
| P value | 0.26 | 0.30 | 0.11 |
| Haplotypes 2 and 4c | |||
| 1/2 and 0 copies | 6.6 (48) | 12.5 (45) | 77.3 (50) |
| 0 and 0 copies | 8.7 (162) | 15.5 (147) | 72.8 (166) |
| 1/2 and 1/2 copies | 8.7 (11) | 18.4 (11) | 70.7 (12) |
| 0 and 1/2 copies | 9.7 (48) | 21.1 (42) | 66.0 (49) |
| P value | 0.032 | <0.001 | <0.001 |
a
The multivariate models was as follows: %iAs (natural log (ln) transformed) = β1 × haplotype + β2 × gender + β3 × smoking + β4 × county + β5 × BMI;
%MMA (ln) = β1 × haplotype + β2 × gender + β3 × smoking + β4 × BMI;
%DMA = β1 × haplotype + β2 × gender + β3 × smoking + β4 × county + β5 × BMI;
b
P values presented are for haplotype term as a whole in the multivariate regression (β1 × haplotype).
c
Number of copies of haplotype 2 are denoted first. The groups are in order of expected effect (the groups with the lowest expected %MMA are first), based on the analysis of the haplotypes separately.