Table 1.

Geometric mean adult flea ( Ctenocephalides felis) counts and percent efficacy relative to non-treated controls for dogs treated with a topical spot-on formulation of fipronil and permethrin

Water exposure study days	No water exposure			2 or 3 water immersions (on D10, and 24, or on D10, D17 and 24, respectively)						1 shampooing (on D17)
	Study 1 1			Study 2 2			Study 3 2			Study 4 2			Study 5 2
	Flea counts		Efficacy (%)	Flea counts		Efficacy (%)	Flea counts		Efficacy (%)	Flea counts		Efficacy (%)	Flea counts		Efficacy (%)
	Control group 3	Treated group 3		Control group 3	Treated group 3		Control group 3	Treated group 3		Control group 3	Treated group 3		Control group 3	Treated group 3
	(n = 8)	(n = 8)		(n = 8)	(n = 8)		(n = 8)	(n = 8)		(n = 8)	(n = 8)		(n = 8)	(n = 8)
D1-2	55.3	0.44	99.3	67.2	0.74	99.0	62.0	0.04	100.0	74.3	0.04	100.0	67.4	0.34	99.5
D8-9	79.4	0.04	100	55.4	0.04	100.0	79.4	0.04	100.0	86.9	0.04	100.0	59.9	0.04	100.0
D15-16	84.9	0.04	100	64.9	0.04	100.0	78.9	0.04	100.0	85.9	0.04	100.0	63.2	0.14	99.9
D22-23	86.8	0.24	99.8	68.0	0.04	100.0	87.2	0.04	100.0	97.9	0.04	100.0	73.4	0.04	100.0
D29-30	89.3	1.44	98.4	62.0	0.04	100.0	82.0	0.04	100.0	89.8	0.04	100.0	67.1	0.34	99.6

¹In study 1, fleas were counted and removed 24 h after treatment or infestation.

²In studies 2, 3,4 and 5, fleas were counted and removed 48 h after treatment or infestation.

³Geometric mean flea count.

⁴Treated group differed statistically significantly (p < 0.005) from the untreated Control group.