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. 2014 Aug 26;1:140021. doi: 10.1038/sdata.2014.21

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Copyright © 2014, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0 Metadata associated with this Data Descriptor is available at http://www.nature.com/sdata/ and is released under the CC0 waiver to maximize reuse.

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This Figure was modified from Figure 1a presented in the related research manuscript. The study was comprised of a training set and a test set with the text on the right detailing the experimental design. RNA-Seq was used to profile molecular events related to treatment of rats by each chemical; each chemical is known to associate with a specific mode of action (MOA). For each MOA there were three representative chemicals and three biological replicates per chemical. The training set consisted of 15 chemicals and 5 MOAs.The test set consisted of 12 chemicals and 4 MOAs. Of the 4 MOAs in the test set two (PPARA and CAR/PXR) appeared in the training set while the other two did not.