Table 1. Modes of action and exposure of the chemicals used in the study.

SET	MIE/MOA	Chemical Name	Abbreviation	Dose (mg/kg/day)	Duration (days)	Structure Activity Group; Therapeutic indication
MOA denotes the mode of action. MIE denotes the molecular initiating event. Dose unit is mg/kg/day and the unit for duration is day.
This table is taken from Supplementary Table 2 in the related research manuscript.
TRAINING	AHR	3-METHYLCHOLANTHRENE	3ME	300	5	Toxicant, Ah receptor agonist, DNA alkylator
TRAINING	AHR	BETA-NAPHTHOFLAVONE	NAP	1500	5	Toxicant, Ah receptor agonist
TRAINING	AHR	LEFLUNOMIDE	LEF	60	5	Inhibits pyrimidine /purine metabolism, dihydroorotase inhibitor; Antirheumatic Disease Modifying Agent
TRAINING	CAR/PXR	ECONAZOLE	ECO	334	5	Sterol 14-demethylase inhibitor, fluconazole like; Antifungal azole
TRAINING	CAR/PXR	METHIMAZOLE	MET	100	3	Thyroperoxidase inhibitor; Thyroid and Antithyroid Agent
TRAINING	CAR/PXR	PHENOBARBITAL	PHE	54	5	GABA agonist; Antiepileptics / Anticonvulsants
TRAINING	CYTOTOX	CARBON TETRACHLORIDE	CAR	1175	7	Toxicant, free radical generator
TRAINING	CYTOTOX	CHLOROFORM	CHL	600	5	Toxicant, free radical generator
TRAINING	CYTOTOX	THIOACETAMIDE	THI	200	5	Toxicant, free radical generator
TRAINING	DNA DAMAGE	AFLATOXIN B1	AFL	0.3	5	Toxicant, DNA alkylator
TRAINING	DNA DAMAGE	IFOSFAMIDE	IFO	143	3	DNA-alkylator, nitrogen mustard; Antineoplastic
TRAINING	DNA DAMAGE	N-NITROSODIMETHYLAMINE	NIT	10	5	Toxicant, DNA alkylator
TRAINING	PPARA	BEZAFIBRATE	BEZ	617	7	Peroxisome proliferator; Hypolipidemic Agent
TRAINING	PPARA	NAFENOPIN	NAF	338	5	Peroxisome proliferator; Hypolipidemic Agent
TRAINING	PPARA	PIRINIXIC ACID	PIR	364	5	Peroxisome proliferator; Hypolipidemic Agent
TEST SET	CAR/PXR	CLOTRIMAZOLE	CLO	89	5	Sterol 14-demethylase inhibitor; Antifungal azole
TEST SET	CAR/PXR	FLUCONAZOLE	FLU	394	5	Sterol 14-demethylase inhibitor, fluconazole like; Antifungal azole
TEST SET	CAR/PXR	MICONAZOLE	MIC	920	5	Sterol 14-demethylase inhibitor, fluconazole like; Antifungal azole
TEST SET	ER	BETA-ESTRADIOL	BES	150	5	Estrogen receptor agonist, steroidal; Bone Mineral Homeostasis
TEST SET	ER	ETHINYLESTRADIOL	EES	10	5	Estrogen receptor agonist, steroidal; Hormone replacement
TEST SET	ER	NORETHINDRONE	NOR	375	5	Progesterone receptor agonist; Ovulation inhibitor
TEST SET	HMGCOA	CERIVASTATIN	CER	7	5	HMG-CoA reductase inhibitor; Hypolipidemic Agent
TEST SET	HMGCOA	LOVASTATIN	LOV	450	5	HMG-CoA reductase inhibitor, non-aromatic; Hypolipidemic Agent
TEST SET	HMGCOA	SIMVASTATIN	SIM	1200	3	HMG-CoA reductase inhibitor, non-aromatic; Hypolipidemic Agent
TEST SET	PPARA	CLOFIBRIC ACID	CFA	448	5	PPAR alpha agonist, fibric acid; Hypolipidemic Agent
TEST SET	PPARA	GEMFIBROZIL	GEM	700	7	PPAR alpha agonist, fibric acid; Hypolipidemic Agent
TEST SET	PPARA	ROSIGLITAZONE	ROS	1800	5	PPAR gamma agonist, thiazolidinedione, antidiabetic