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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Neuropharmacology. 2014 Jul 3;86:38–48. doi: 10.1016/j.neuropharm.2014.06.022

Figure 6.

Figure 6

PACAP infusions into the CeA decrease open arm entries on the elevated plus maze. Adult rats were cannulated as described in Methods for CeA PACAP infusions. Thirty minutes after PACAP injection, the animals were placed in the center square of the elevated plus maze, facing a closed arm, for behavior testing during a 5 min period. All movements were tracked digitally for data analyses. Total open arm entries (A) and open arm preference (B, open arm entries/total arm entries) were calculated. CeA PACAP signaling significantly increased anxiety-like behavior reflected by decreased number of open arm entries and open arm preference. There were no changes in the number of closed arm entries and there were no indications of freezing behaviors. n = 10 per group, data represent mean ∀ SEM, *, different from vehicle control p < 0.05.