Table 1.

Diversity of PTMs catalyzed by Dot/Icm effectors of Legionella pneumophila.

PTMs	Mechanism	Effector name	Motif	Target	Reference
Phosphorylation
		LegK1	STPK	IκB	Ge et al. (2009); Hervet et al. (2011)
		LegK2	STPK		Hervet et al. (2011)
		LegK3	STPK		Hervet et al. (2011)
		LegK4	STPK		Hervet et al. (2011)
Methylation		LegAS4/RomA	SET domain	H3	Li et al. (2013), Rolando et al. (2013b)
Prenylation		AnkB/LegAU13/Ceg27	CAAX		Price et al. (2010a)
Ubiquitination
		LubX/LegU2	U-box	Clk1 /SidH	Kubori et al. (2008)
		AnkB/LegAU13 /Ceg27	F-box	Skp1/ParvB	Price et al. (2009), Lomma et al. (2010)
		LegU1	F-box	BAT3	Ensminger and Isberg (2010)
		SidC			Hsu et al. (2014)
Glycosylation
		Lgt1	Coiled- coil	eEF1A	Belyi et al. (2006)
		Lgt2	Coiled- coil	eEF1A	Belyi et al. (2008), Aktories (2011)
		Lgt3/Legc5	Coiled- coil	eEF1A	Belyi et al. (2008), Aktories (2011)
		SetA			Heidtman et al. (2009)
AMPylation		SidM/DrrA		Rab1	Müller et al. (2010)
DeAMPylation		SidD		Rab1	Neunuebel et al. (2011); Tan et al. (2011)
Phosphocholination		AnkX /AnkN /LegA8	Ankyrin	Rab1	Mukherjee et al. (2011)
Dephosphocholination		Lem3		Rab1	Tan et al. (2011)

STPK, Ser/Thr protein kinase.