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. 2015 Feb 10;9:20. doi: 10.3389/fncel.2015.00020

Figure 1.

Figure 1

Systemic administration of TRPV1 agonist CAP increased the severity of seizure while the antagonist CPZ reduced the susceptibility to PTZ-induced seizures. (A) Injection of CAP (40 mg/kg, i.p.) immediately induced TCS even without PTZ induction. In contrast, the latency to TCS was significantly delayed in 5, 10 mg/kg CAP, and ESM groups compared with the vehicle group. (B) Both 5 and 10 mg/kg CAP had the tendency to increase the grades of seizure except ESM compared with the vehicle group. (C) 5, 10, and 40 mg/kg CAP increased the mortality except ESM compared with the vehicle mice. (D) The latency to TCS was significantly increased in 0.05, 0.5, 1 mg/kg CPZ, and ESM groups compared with the control group. (E) 0.05, 0.5, and 1 mg/kg CPZ had no effect on the grades of PTZ-induced seizures except ESM. (F) 0.05, 0.5 mg/kg CPZ, and ESM groups showed decreased mortality but not in 1 mg/kg CPZ group compared with the vehicle group. The number in the bars of panel (C, F) represents the mice number of death or survival, respectively. All data are expressed as mean ± SEM. **p < 0.01. ***p < 0.001.