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. 2015 Feb 10;9:20. doi: 10.3389/fncel.2015.00020

Figure 2.

Figure 2

Decreased susceptibility to PTZ-induced seizures in TRPV1 knockout mice and hippocampal TRPV1 overexpression mice. (A) The latency to TCS in the TRPV1 knockouts was delayed compared with WT mice. (B) The development of seizure was reduced in TRPV1 knockout mice than WT mice. (C) The TRPV1 knockout mice also showed decreased mortality. (D) Longer latency to TCS of hippocampal TRPV1 overexpression (OE) mice than WT mice. (E) Reduced seizure development of hippocampal TRPV1 OE mice compared with the WT group. (F) Lower mortality in hippocampal TRPV1 OE mice. All data are expressed as mean ± SEM. *p < 0.05. **p < 0.01.