Table 1.
List of materials produced and processed by EHDA
| Materials | Sizes | Solvents | References |
|---|---|---|---|
| Pharmaceutics/drugs | |||
| Aspirin | ≈ 6 μm | Ethanol | Li et al., 2006 |
| Methylparahydroxybenzoate | 1.58–4.55 μm | Ethanol | Ijsebaert et al., 2006 |
| Beclomethasone dipropionate | 1.5–4.5 μm | Ethanol | Ijsebaert et al., 2006 |
| Paclitaxel | ≈ 10 μm | Ethanol | unpublished |
| Carbamazepine | 0.32–1.75 μm | Methanol | Wang et al., 2011 |
| Indomethacin | 1.7 μm | Ethanol | Nystrom et al., 2011 |
| Piroxicam | 5.5 μm | Chloroform | Nystrom et al., 2011 |
| Budesonide | 4.9 μm | Chloroform | Nystrom et al., 2011 |
| Niflumic acid | 0.2–0.8 μm | Acetone/water | Ambrus et al., 2013 |
| Biological materials | |||
| Insulin | 110 nm | ethanol/water/HCl | Gomez et al., 1998 |
| BSA | 700 nm | ethanol/acetic acid | Cardoso et al., 2011 |
| Sucrose (C12H22O11) | 20 nm | Water | Morozov et al., 2011 |
| Sericin | 25–175 nm | DMSO | Hazeri et al., 2012 |
| Silk-elastin-like protein | 24 and 36 nm | ammonium acetate buffer | Anumolu et al., 2011 |
| DNAs | Water | Chen et al., 2000; Okubo et al., 2008 | |
| Cells | Abeyewickreme et al., 2009; Ng et al., 2011; Sahoo et al., 2012; Braghirolli et al., 2013 | ||
| Whole organism | Mongkoldhumrongkul et al., 2010; Clarke et al., 2008 | ||
| Natural polymers | |||
| Chitosan | 124 nm and ≈ 2.5 μm | Ethanol/acetic acid/water | Arya et al., 2009; Pancholi et al., 2009; Zhang and Kwakami, 2010 |
| Cellulose | ≈ 1 μm | Ethanol and butanone/DCM | Huang et al., 2012; Bodnar and Rosell-Llompart, 2013 |
| Alginate | 0.15 to 2 mm | Water | Moghadam et al., 2008; Xie and Wang, 2007; Tabeei et al., 2012; Park et al., 2012 |
| Synthetic polymers | |||
| PS | ≈ 0.75 – 5 | THF | Fantini et al., 2006 |
| PCL | 0.3 – 20 μm | DCM/chloroform/DMAc | Ding et al., 2005; Wu and Clark, 2007; Enayati et al., 2010; Bock et al., 2011 |
| PLGA | 0.06 – 15 μm | DCM/acetonitrile/TFE/DMSO/TEAF | Xie et al., 2006a; Xie et al., 2006b; Almeria et al., 2010; Almeria et al., 2014; Berkland et al., 2004 |
| PLA | 3.7 – 19 μm | 1-butanol/methylene chloride/1,2-dichloroethane-ethanol (DCE)/chloroform | Yeo et al., 2005; Xu et al., 2006; Ikeuchi et al., 2012 |
| Polymer/polymer blends | |||
| PLA/PLGA | ≈ 5 μm | DCM-DMSO | Xie et al., 2008 |
| PLGA/Pluronics | ≈ 1.4–1.6 μm | THF-DMF | Seth and Katti, 2012 |
| Drug/polymer | |||
| Taxol/PCL | 3–10 | DCM-Acetonitrile | Ding et al., 2005 |
| Paclitaxel/PLGA | 17–32 | DCM-Acetonitrile | Xie et al., 2006b; Naraharisetti et al., 2007; Ranganath et al., 2009a, b |
| Beclomethasone-dipropionate/PLA | 230–850nm | DCM-Ethanol | Valo et al., 2009 |
| Celecoxib/PLGA | 2–8 μm | Acetonitrile | Bohr et al., 2012 |
| Ketoprofen/ethyl cellulose | Ethanol aqueous | Huang et al., 2012 | |
| Piperine/p-coumaric acid-thiolated-chitosan | 2–5μm | Lactic acid | Pengpong et al., 2014 |
| Quercetin/PVP, SDS, sucralose | 1.3–1.8 μm | Dimethylacetamide-Ethanol | Li et al., 2014 |
| Griseofulvin/poly (methacrylic acid-co-methyl methacrylate) | 1 μm | Zhang et al., 2011 | |
| BSA/lysozyme/PLGA | ~20 μm | DCM-water | Xie et al., 2007 |
| Salbutamol-sulfate/PLA | 230–850nm | DCM-Ethanol | Valo et al., 2009 |
| BSA/PCL-PPE-EA | 2–4 μm | Water-DCM | Wu et al., 2010b |
| Ovalbumin/calcium alginate | 1.0–1.5 μm | Water | Sukasamran et al., 2013 |
| BSA/PDMS | 5–6 μm | Water-acetone | Pareta and Edirisinghe et al., 2006 |
| Budesonide/PLGA | ~3 μm | Acetonitrile | Lee et al., 2010c |
| Paclitaxel/suramin/PLLA/PLGA | 10–20 μm | DCM-Ethyl Acetate | Nie et al., 2010a,b |
| Doxorubicin/elastin-like polypeptide | 150–570nm | Water | Wu et al., 2009b |
| Imidazoquinoline/acetalated dextran or acetalated dextran/tween blends | ~2 μm | ||
| Trifluoroethanol/methanol/ethanol/1-propanol/1-b | Duong et al., 2013 | ||
| Irinotecan/acetalated dextran/PLGA | 8.4 μm | DMF | Rahmani et al., 2013 |
| Cisplatin/maleimide-PEG-PLGA | ~550nm | Ether/methanol | Bai and Liu, 2014 |
| Gemcitabine/folate-chitosan | 200–300nm | Xu et al., 2013 | |
| DNA | |||
| pCIKLux | Ethanol-water-ethanoic acid | Davies et al., 2005 | |
| Plasmid DNA/PEI | Wu et al., 2010a | ||
| Oblimerson sodium/Genasense/lipoplex | 100–2500 nm | PBS\ethanol | Wu et al., 2009a |
| pET30a-GFP plasmid/gold nanoparticles | 20–50 nm | water | Lee et al., 2011b |
| Adenovirus/alginate | <150 μm | Water | Park et al., 2012a |
| Food | |||
| Chocolate (fat, sugar, lecinthin) | Melt | Gorty and Barringer, 2011; Luo et al., 2012 | |
| Cocoa butter, coca butter equivalent, lauric butter | Melt | Marthina and Barringer, 2012 | |
| Zein-curcumin | 175–900 nm | Aqueous-ethanol | Gomez-Estaca et al., 2012 |
| Stearic acid-ethylcellulose-Maltol | 10–100 nm | Ethanol | Eltayeb et al., 2013 |
| Composites | |||
| Polystyrene/silica nanoparticles | 60–100 μm | water | Moon et al., 2004; Shen et al., 2010 |
| TiO2-PMMA | 0.25–1.87 μm | Diethylene glycol dimethyl ether | Yun et al., 2009 |
| CdSeS-poly(styrene-acrylate) | 500–1000nm | DMF | Sun et al., 2011 |
| PVA-MMT/Ag | ~ 4 μm | DMF/THF | Park et al., 2012; Park et al., 2011; Park et al., 2013 |
| Polystyrene-block-ethylene oxide-quantum dots/iron oxide | 36–38 nm | Water | Duong et al., 2014 |
| Metals | |||
| Sn-Bi | 5–50 nm | melt | Yu and Hu, 1997 |
| Au | 7.1 nm, 10.9 nm 14.9 nm | Water-methanol | Lengoro et al., 2002 |
| Pd | 4.3 nm | Water-methanol | Lengoro et al., 2002 |
| Al | 4–14 μm | Ether-ethanol | Wang et al., 2013 |
| Carbon | |||
| Carbon nanotubes | ~100 nm | Methanol | Jennerjohn et al., 2010; Kim et al., 2010; Wang et al., 2013 |
| Graphene | ~1 μm | Water | Tian et al., 2013 |
| Inorganic materials | |||
| TiO2 | 10 – 20 nm | Ethanol | Park et al., 1996; Wang et al., 2005; Terada et al., 2012 |
| TiO2/ZrOx | 110 nm 2–4 μm | 1-BuOH | Borra et al., 1999a; Camelot et al., 1999 |
| CeO2 | 24.6 and 29.9 nm | Ethanol/diethylene glycol butyl ether | Oh and Kim, 2007 |
| ZnS | 20–40 nm | Ethyl alcohol | Lenggoro et al., 2000 |
| Ce2O3/TiO2 | 80–500nm | Mou et al., 2013 | |
| BiFeO3 | Du et al., 2011 | ||
| Li4/3Ti5/3O4 | 10 nm | 2-propanol-acetic acid | Doi et al., 2009 |
| Nano-sized Hydroxyapatite | Li et al., 2007 | ||
| Gas | |||
| Microbubble (air) | <10 μm | Farook et al., 2007a, b; Pancholi et al., 2007; Farook et al., 2009 | |
Abbreviations: PLGA, Poly(lactic-co-glycolic acid); PLA, Polylactic acid; PCL, Poly(3-caprolactone); PHBV, Poly(3-hydroxybutyrate-co-3-hydroxyvalerate); TEAF: Triethyl ammonium formate