Table 3.

Number of subjects with score >30 according to the Zung Depression Self-Rating Scale

Time	Amitriptyline (A)	P (vs T=0)	SAMe/betaine (B)	P (vs T=0)	P (B vs A)
T=0	30		30		ns
T=3	30	ns	30	ns	ns
T=6	26	ns	15	<0.01	<0.01
T=12	29	ns	11	<0.01	<0.01

Notes: All values are expressed as median ± standard deviation. Time expressed as months.

Abbreviations: SAMe, S-adenosyl-L-methionine; ns, not significant.