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. Author manuscript; available in PMC: 2015 Feb 10.
Published in final edited form as: Adv Cancer Res. 2014;124:31–82. doi: 10.1016/B978-0-12-411638-2.00002-1

Figure 2.1.

Figure 2.1

(A) CXCL12 is highly expressed in tissues like lungs, liver, and bone marrow and is also secreted by tumor and stromal cells. CXCR4/CXCL12 interaction results in increased proliferative, migratory, and invasive properties of tumor cells that enable them to escape from primary tumors. CXCR4-expressing tumor cells migrate toward CXCL12 gradient and home to organs that release CXCL12. (B) Schematic diagram of CXCR4/CXCL12 signaling pathway.