TABLE 2.

Patient and Disease Characteristics by Histologic Subtype (N = 49)

	Typical (n = 17)		Atypical (n = 32)
Characteristics	No.	%	No.	%	pa
Age at diagnosis (yr)					0.117
Median and (IQR)	50	(47–57)	58	(47–64)
Sex					0.715
Male	6	35.3	13	40.6
Female	11	64.7	19	59.4
Smoking status					0.234
Ever smoked	6	35.3	17	53.1
Never smoked	11	64.7	15	46.9
Prior curative resection					0.845
Yes	9	52.9	16	50
No	8	47.1	16	50
Time to recurrence (mo)					0.008b
Median	119		66
Advanced disease stage (IASLC Seventh Edition)					0.855
Locally advanced	3	17.7	5	15.6
IIIA	1		2
IIIB	2		3
Metastatic (stage IV)	14	82.3	27	84.4
Stage at initial presentation (TNM)
T1A/B N0/X M0	2		1
T1A N2 M0	0		1
T2A/B N0 M0	1		2
T2A/B N1 M0	2		0
T2A/B N2 M0	1		7
T3 N0 M0	1		0
T3 N2 M0	0		2
T3 N3 M0	0		1
T4 N1 M0	1		0
T4 N2/3 M0	2		2
T2B N0 M1A	2		0
T4 N1 M1A	1		2
T2A/B N0/X M1B	2		4
T3 N1/X M1B	1		6
T4 NX M1B	2		4
Metastatic disease sites
Liver	10	58.8	19	59.4
Pleura/mediastinum/contralateral lung	8	47.1	10	31.3
Bone	7	41.2	11	34.4
Brain/meninges	0	0	6	18.9
Other	2	11.8	5	15.6
Carcinoid syndrome					0.015
Yes	6	35.3	2	6.3
No	11	64.7	30	93.7
Chromogranin A level (serum)					0.025
Increased	9	52.9	6	18.8
Normal	6	35.3	12	37.5
Result not available	2	11.8	14	43.7

^aχ² test for homogeneity or Fisher’s exact test for binary and categorical variables and nonparametric Mann–Whitney U test for continuous variables.

^bLog-rank test.

IQR, interquartile range; IASLC, International Association for the Study of Lung Cancer; TNM, tumor, node, metastasis.