Skip to main content
. Author manuscript; available in PMC: 2015 Feb 10.
Published in final edited form as: Circulation. 2007 Jan 29;115(7):909–917. doi: 10.1161/CIRCULATIONAHA.106.662296

Figure 2.

Figure 2

Mitochondrial respiration is inefficient in insulin-resistant UCP-DTA hearts. A, Mitochondrial respiration rates (V̇o) in saponin-permeabilized muscle strips prepared from NTG and UCP-DTA hearts in the presence of palmitoyl-l-carnitine/malate. Mean values (±SE) are shown for basal, state 3 (ADP-stimulated), and oligomycin-inhibited (oligo) respiration. The respiratory control (RC) ratio represents the ratio of oligo to state 3 respiration; n=6 animals/group. B, ATP synthesis rates (left) and ratio of ATP synthesis to maximal V̇o (ATP/O; right) obtained from the same muscle strips shown in Figure 2A. *P<0.05 compared with NTG value. mg dw indicate milligrams of dry weight.