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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Pharmacol Ther. 2014 Aug 25;0:85–91. doi: 10.1016/j.pharmthera.2014.08.004

Fig. 2.

Fig. 2

A simplified, theoretical model comparing the effects of a hypothetical selective GR ligand on the expression of a GR:KLF15 coherent feed-forward target, AASS, and a GR:KLF15 incoherent feed-forward target, MT2A. A. With a standard GR ligand, shown as a blue circle, AASS expression is induced to level Ȳ, based on the combinatorial activity of both GR and KLF15. B. Similar to A, MT2A is induced to level , which represents combined inductive effects of GR and repressive effects of GR-induced KLF15. C. Here, a selective GR ligand, shown as an orange circle, causes GR to induce 50% of the expression level of KLF15 and AASS that was achieved with the standard ligand. However, the final level of AASS expression is 25% Ȳ, since lower GR-induced KLF15 levels lead to further decreases in AASS expression. D. Here the putative effects of the selective GR ligand are shown on the expression of the incoherent feed-forward target, MT2A. In this case, reduced GR-mediated induction of KLF15 in part balances the reduced inductive effect of GR on MT2A, leading to 75% expression of MT2A.