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Phosphortlated Smad3 is stabilized by ERG in ERG-positive prostate cancer cells. Smad3 is phosphorylated by TGF-β binding to receptor. Phosphorylated Smad3 forms a complex with phosphorylated Smad2 and the common Smad (Smad4) and translocates to the nucleus. Phosphorylated Smad3 is stabilized by binding to ERG in the nucleus.
