Table 1.
Minimum inhibitory concentrations (MIC 50 , MIC 90 , MIC range [mg/L]) and antimicrobial susceptibility (%S) of clinically important Gram-positive and Gram-negative isolates
| Pathogen | N | MIC 50 | MIC 90 | MIC Range | %S |
|---|---|---|---|---|---|
| Gram-positive | |||||
| E. faecalis | |||||
| AMC | 969 | 0.5 | 1 | ≤0.03 - ≥16 | 99.1 |
| AMP | 969 | 1 | 2 | ≤0.06 - ≥32 | 98.8 |
| IMP | 137 | 1 | 4 | ≤0.12 - 16 | 96.4 |
| LZD | 969 | 2 | 2 | ≤0.5 - 4 | 100 |
| TIG | 969 | 0.12 | 0.25 | ≤0.008 - 0.5 | 99.8 |
| VAN | 969 | 1 | 2 | 0.25 - ≥64 | 99.3 |
| E. faecium | |||||
| AMC | 332 | ≥16 | ≥16 | 0.06 - ≥16 | 25.0 |
| AMP | 332 | ≥32 | ≥32 | ≤0.06 - ≥32 | 22.3 |
| IMP | 29 | ≥32 | ≥32 | 2 - ≥32 | 20.7 |
| LZD | 332 | 2 | 2 | ≤0.5 - 2 | 100 |
| TIG | 332 | 0.06 | 0.25 | 0.03 - 0.25 | 100 |
| VAN | 332 | 1 | 2 | 0.25 - ≥64 | 94.6 |
| S. aureus | |||||
| LEV | 2229 | 0.25 | 16 | ≤0.06 - ≥64 | 71.7 |
| LZD | 2229 | 2 | 2 | ≤0.5 - 4 | 100 |
| MIN | 2229 | ≤0.25 | 0.5 | ≤0.25 - ≥16 | 93.7 |
| PEN | 2229 | 8 | ≥16 | ≤0.06 - ≥16 | 14.4 |
| TIG | 2229 | 0.12 | 0.25 | ≤0.008 - 0.5 | 100 |
| VAN | 2229 | 1 | 1 | ≤0.12 - 2 | 100 |
| S. agalactiae | |||||
| LEV | 859 | 0.5 | 1 | ≤0.06 - 32 | 97.1 |
| LZD | 859 | 1 | 1 | ≤0.5 - 2 | 100 |
| MIN | 859 | 8 | ≥16 | ≤0.25 - ≥16 | 15.4 |
| PEN | 859 | ≤0.06 | 0.12 | ≤0.06 - 0.12 | 100 |
| TIG | 859 | 0.06 | 0.12 | 0.015 - 0.25 | 100 |
| VAN | 859 | 0.5 | 0.5 | ≤0.12 - 1 | 100 |
| S. pneumoniae | |||||
| AMP | 990 | ≤0.06 | 2 | ≤0.06 - ≥32 | 68.2 |
| AZI | 872 | 0.12 | ≥128 | ≤0.03 - ≥128 | 56.5 |
| CRO | 990 | 0.06 | 1 | ≤0.03 - 16 | 79.1 |
| CLA | 872 | 0.06 | ≥128 | ≤0.015 - ≥128 | 57.0 |
| CLI | 872 | 0.06 | ≥128 | ≤0.015 - ≥128 | 65.0 |
| ERY | 872 | 0.12 | ≥128 | ≤0.015 - ≥128 | 56.4 |
| IMP | 120 | ≤0.12 | 0.25 | ≤0.12 - 0.5 | 100 |
| LEV | 990 | 1 | 1 | ≤0.06 - ≥64 | 99.6 |
| LZD | 990 | 1 | 1 | ≤0.5 - 4 | 99.9 |
| MER | 870 | ≤0.12 | 0.5 | ≤0.12 - ≥32 | 99.9 |
| MIN | 990 | 1 | 8 | ≤0.25 - ≥16 | 47.6 |
| PEN | 990 | ≤0.06 | 2 | ≤0.06 - ≥16 | 51.3 |
| VAN | 990 | 0.25 | 0.5 | ≤0.12 - 1 | 100 |
| Gram-negative | |||||
| E. aerogenes | |||||
| AMK | 561 | 2 | 8 | ≤0.5 - 64 | 95.9 |
| CFP | 561 | ≤0.5 | 2 | ≤0.5 - ≥64 | 87.0 |
| CRO | 561 | 0.5 | 32 | ≤0.06 - ≥128 | 56.7 |
| IMP | 81 | 0.5 | 1 | ≤0.06 - 4 | 97.5 |
| LEV | 561 | 0.06 | ≥16 | ≤0.008 - ≥16 | 76.5 |
| MER | 480 | ≤0.06 | 0.12 | ≤0.06 - 8 | 98.3 |
| PTZ | 561 | 8 | 64 | 0.25 - ≥256 | 59.5 |
| TIG | 561 | 0.5 | 2 | 0.12 - 16 | 87.0 |
| E. cloacae | |||||
| AMK | 1665 | 1 | 4 | ≤0.5 - ≥128 | 96.7 |
| CFP | 1665 | ≤0.5 | 8 | ≤0.5 - ≥64 | 66.5 |
| CRO | 1665 | 1 | ≥128 | ≤0.06 - ≥128 | 50.7 |
| IMP | 226 | 0.5 | 1 | ≤0.06 - 8 | 99.1 |
| LEV | 1665 | 0.06 | ≥16 | ≤0.008 - ≥16 | 73.1 |
| MER | 1439 | ≤0.06 | 0.25 | ≤0.06 - ≥32 | 99.4 |
| PTZ | 1665 | 4 | ≥256 | ≤0.06 - ≥256 | 59.3 |
| TGC | 1665 | 0.5 | 2 | 0.06 - 16 | 85.0 |
| E. coli | |||||
| AMK | 2284 | 2 | 4 | ≤0.5 - ≥128 | 97.9 |
| AMC | 2284 | 8 | 32 | 0.25 - ≥64 | 70.8 |
| AMP | 2284 | ≥64 | ≥64 | ≤0.5 - ≥64 | 38.4 |
| CFP | 2284 | ≤0.5 | 8 | ≤0.5 - ≥64 | 84.3 |
| CRO | 2284 | ≤0.06 | 64 | ≤0.06 - ≥128 | 84.0 |
| IMP | 324 | 0.25 | 0.5 | ≤0.06 - 2 | 100 |
| LEV | 2284 | 0.03 | ≥16 | ≤0.008 - ≥16 | 79.9 |
| MER | 1960 | ≤0.06 | ≤0.06 | ≤0.06 - 4 | 99.9 |
| PTZ | 2284 | 2 | 16 | ≤0.06 - ≥256 | 89.0 |
| TGC | 2284 | 0.25 | 0.5 | ≤0.008 - 2 | 99.3 |
| H. influenzae | |||||
| AMC | 1191 | 0.5 | 1 | ≤0.12 - 16 | 99.2 |
| AMP | 1191 | ≤0.5 | 32 | ≤0.5 - ≥64 | 75.6 |
| CRO | 1191 | ≤0.06 | ≤0.06 | ≤0.06 - 4 | 98.5 |
| IMP | 156 | 0.25 | 0.5 | ≤0.06 - 4 | 98.7 |
| LEV | 1191 | 0.015 | 0.015 | ≤0.008 - 1 | 100 |
| MER | 1035 | ≤0.06 | 0.12 | ≤0.06 - 0.5 | 100 |
| MIN | 1191 | ≤0.5 | 1 | ≤0.5 - 16 | 90.8 |
| K. oxytoca | |||||
| AMK | 695 | 1 | 4 | ≤0.5 - ≥128 | 98.7 |
| AMC | 695 | 2 | 32 | 0.25 - ≥64 | 79.7 |
| CFP | 695 | ≤0.5 | 2 | ≤0.5 - ≥64 | 89.2 |
| CRO | 695 | ≤0.06 | 8 | ≤0.06 - ≥128 | 83.3 |
| IMP | 102 | 0.25 | 0.5 | ≤0.06 - 1 | 100 |
| LEV | 695 | 0.06 | 1 | ≤0.008 - ≥16 | 90.5 |
| MER | 593 | ≤0.06 | ≤0.06 | ≤0.06 - ≥32 | 99.7 |
| PTZ | 695 | 2 | ≥256 | ≤0.06 - ≥256 | 83.3 |
| TGC | 695 | 0.25 | 1 | 0.015 - 8 | 95.4 |
| K. pneumoniae | |||||
| AMK | 1524 | 1 | 4 | ≤0.5 - ≥128 | 96.4 |
| AMC | 1524 | 4 | 32 | 0.5 - ≥64 | 72.6 |
| CFP | 1524 | ≤0.5 | 32 | ≤0.5 - ≥64 | 79.4 |
| CRO | 1524 | ≤0.06 | ≥128 | ≤0.06 - ≥128 | 77.2 |
| IMP | 211 | 0.25 | 0.5 | ≤0.06 - 2 | 100 |
| LEV | 1524 | 0.06 | 8 | ≤0.008 - ≥16 | 82.2 |
| MER | 1313 | ≤0.06 | ≤0.06 | ≤0.06 - ≥32 | 99.6 |
| PTZ | 1524 | 2 | 64 | 0.12 - ≥256 | 81.3 |
| TGC | 1524 | 0.5 | 2 | 0.06 - 16 | 87.6 |
| S. marcescens | |||||
| AMK | 895 | 2 | 4 | ≤0.5 - ≥128 | 97.1 |
| CFP | 895 | ≤0.5 | 1 | ≤0.5 - ≥64 | 94.4 |
| CRO | 895 | 0.25 | 8 | ≤0.06 - ≥128 | 80.4 |
| IMP | 118 | 0.5 | 1 | ≤0.06 - 4 | 96.6 |
| LEV | 895 | 0.12 | 2 | 0.015 - ≥16 | 87.2 |
| MER | 777 | ≤0.06 | 0.12 | ≤0.06 - ≥32 | 98.7 |
| PTZ | 895 | 2 | 16 | ≤0.06 - ≥256 | 88.7 |
| TGC | 895 | 1 | 2 | 0.015 - 8 | 80.1 |
| A. baumannii | |||||
| AMK | 1161 | 4 | 64 | ≤0.5 - ≥128 | 75.6 |
| IMP | 170 | 0.5 | 2 | ≤0.06 - ≥32 | 96.5 |
| LEV | 1161 | 0.25 | 8 | ≤0.008 - ≥16 | 56.8 |
| MER | 991 | 0.5 | 8 | ≤0.06 - ≥32 | 83.7 |
| P. aeruginosa | |||||
| AMK | 1780 | 4 | 16 | ≤0.5 - ≥128 | 87.1 |
| CFP | 1780 | 4 | 32 | ≤0.5 - ≥64 | 77.5 |
| CTZ | 1780 | ≤8 | 32 | ≤8 - ≥64 | 75.6 |
| IMP | 260 | 1 | 8 | 0.12 - ≥32 | 87.7 |
| LEV | 1780 | 1 | ≥16 | ≤0.008 - ≥16 | 58.3 |
| MER | 1520 | 0.5 | 8 | ≤0.06 - ≥32 | 75.4 |
| PTZ | 1780 | 8 | ≥256 | 0.12 - ≥256 | 72.5 |
AMK, amikacin; AMC, amoxicillin-clavulanate; AMP, ampicillin; CFP, cefepime; CTZ, ceftazidime; CRO, ceftriaxone; IMP, imipenem; LEV, levofloxacin; LZD, linezolid; MER, meropenem; MIN, minocycline; PEN, penicillin; PTZ, piperacillin-tazobactam; TIG, tigecycline; VAN, vancomycin.