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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1975 Jan;72(1):318–322. doi: 10.1073/pnas.72.1.318

Methylated nucleotides block 5'-terminus of vaccinia virus messenger RNA.

C M Wei, B Moss
PMCID: PMC432296  PMID: 164018

Abstract

Studies on the nature and location of the methylated nucleotides in mRNA synthesized in vitro by vaccinia virus particles revealed an unusual 5'-terminal structure. Evidence that the pyrophosphate group is blocked by 7-methylguanosine and that both 2'-O-methyl-adenosine and 2'-O-methylguanosine occupy penultimate positions was presented. According to this model, the 5'-termini of vaccinia virus mRNAs are: 7MeG-5'ppp-5'GMepNp and 7MeG-5'AMepNp.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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