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. 2014 Oct 21;5(23):12189–12202. doi: 10.18632/oncotarget.2608

Figure 5. IFN-γ up-regulated PD-L1 expression in human nasopharyngeal carcinoma cells, which was independent of but synergetic with LMP1.

Figure 5

(A) Serum IFN-γ level and EBV DNA copy numbers were measured in 34 NPC patients. Serum IFN-γ level was positively correlated with EBV burden. (B) The protein expression level of PD-L1 and LMP1 (detected by western blot) in CNE-2-vector and CNE-2-LMP1 stable cell lines treated with or without IFN-γ (100 U/ml) for 48 hours. β-actin was used to verify equal loading. (C) Quantified protein expression level of PD-L1 in CNE-2-vector and CNE-2-LMP1 cell lines using Quantity One software (Bio-Rad Laboratories, Hercules, CA) after IFN-γ treatment (100 U/ml) or not.