Figure 7. A schematic representation of Notch signalling and the suggested role of CYLD.

Notch signalling between 2 cells that is mediated by JAG2-NOTCH interaction. The CYLD-MIB2 complex negatively regulates JAG2 expression levels, resulting in a reduction of Notch activation. CYLD knockdown or truncation results in increased JAG2 expression Notch target gene activation (such as RUNX1) in adjacent cells.