Table 1. Notch target genes are upregulated in CYLD defective tumours.
Gene expression data from 32 cylindroma tumours and 10 control perilesional skin samples were pooled into tumour and control groups. Differentially expressed genes with a threshold of p < 0.05 were included and the fold changes (FC) are indicate for the respective transcripts.
| Gene | FC | ILMN Probe ID | Description |
|---|---|---|---|
| DTX3 | 3.13 | ILMN_1658677 | Deltex homolog 3 (Drosophila) |
| HEY1 | 2.73 | ILMN_1788203 | Hairy/enhancer-of-split related with YRPW motif 1 |
| JAG2 | 2.50 | ILMN_2399523 | Jagged 2 |
| HEY1 | 2.43 | ILMN_2407308 | Hairy/enhancer-of-split related with YRPW motif 1 |
| DLL3 | 2.40 | ILMN_1736096 | Delta-like 3 (Drosophila) |
| RUNX1 | 2.33 | ILMN_1801504 | Runt-related transcription factor 1 |
| HOXA9 | 2.19 | ILMN_1739582 | Homeobox A9 |
| TCF3 | 2.09 | ILMN_1664434 | Transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) |
| NFKB2 | 1.91 | ILMN_1799062 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) |
| CD3G | 1.88 | ILMN_1717197 | CD3g molecule, gamma (CD3-TCR complex) |
| JAG2 | 1.87 | ILMN_1764729 | Jagged 2 |
| LEF1 | 1.80 | ILMN_2213136 | Lymphoid enhancer-binding factor 1 |
| NOTCH1 | 1.67 | ILMN_1729161 | Notch homolog 1, translocation-associated (Drosophila) |
| HAT1 | 1.65 | ILMN_1693905 | Histone acetyltransferase type B catalytic subunit |
| PSEN1 | 1.56 | ILMN_1809193 | Presenilin 1 |
| RUNX1 | 1.54 | ILMN_1669335 | Runt-related transcription factor 1 |
| HESX1 | 1.38 | ILMN_1742929 | HESX homeobox 1 |
| FURIN | 0.68 | ILMN_1790228 | Furin (paired basic amino acid cleaving enzyme) |
| PSEN2 | 0.61 | ILMN_1714417 | Presenilin 2 (Alzheimer disease 4) |
| PSEN2 | 0.49 | ILMN_2404512 | Presenilin 2 (Alzheimer disease 4) |
| DLL1 | 0.45 | ILMN_1743373 | Delta-like 1 (Drosophila) |
| CEBPA | 0.44 | ILMN_1715715 | CCAAT/enhancer binding protein (C/EBP), alpha |
| NOTCH3 | 0.43 | ILMN_1658926 | Notch homolog 3 (Drosophila) |
| HES2 | 0.43 | ILMN_2094266 | Hairy and enhancer of split 2 (Drosophila) |
| GATA3 | 0.34 | ILMN_2406656 | GATA binding protein 3 |
| ETS2 | 0.32 | ILMN_1720158 | V-ets erythroblastosis virus E26 oncogene homolog 2 (avian) |