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. 2014 Oct 21;5(23):11752–11777. doi: 10.18632/oncotarget.2555

Figure 1. The Ras/Raf/MEK/ERK pathway and the Ras/PI3K/PTEN/mTOR pathway are activated by external factors such as growth factors and mitogens.

Figure 1

Once RAS is turned on, it recruits and activates proteins necessary for the propagation of growth factor and other receptor signals, such as RAF and PI3K.