Table 1. Cox multivariate analyses for overall survival.

Variables	Overall survival		P value
	HR	95%CI
Age (≥58 vs.<58)	1.071	0.618–1.856	0.807
Gender (male vs. female)	0.636	0.364–1.111	0.112
Tumor size(<5 vs.≥5cm)	1.317	0.775–2.238	0.309
Grading (G1-2 vs.G3)	1.739	0.994–3.204	0.076
TNM stage
I	1.0 (referent)
II	3.265	0.407–26.225	0.266
III	13.114	1.782–96.514	0.011
IV	60.303	7.782–461.924	<0.0001
TSPAN1 protein levels (0-1 vs. 2-3)	2.818	1.355–5.862	0.006

HR: hazard ratio; CI: confidence interval; TNM: tumor–node–metastasis classifications.