Figure 1. Effects of CPT-11 treatment in combination with MBL-II-141 on tumor growth and mice survival.

(A) HEK-pcDNA3 and (B) HEK-ABCG2 xenografts were implanted sub-cutaneously into mice. After onset of the tumors, mice were treated three times a week by: corn oil/0.5% DMSO + PBS (black crosses), MBL-II-141 at 10 mg/kg + PBS (green squares), corn oil/5% DMSO + CPT-11 at 20 mg/kg (orange triangles) and MBL-II-141 at 10 mg/kg + CPT-11 at 20 mg/kg (blue circles). The treatments started at day 21 and lasted until day 108. **P < 0.001