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MBL-II-141 alone (at 10 mg/kg) or in combination with 20 mg/kg of CPT-11 was intraperitoneally administered to SCID mice. Blood, brain and liver were taken for LC-MS/MS analysis after 30, 60, 120, 240 or 360 min for treatments with MBL-II-141 alone, and after 30, 60, 120, 240 or 480 min for combination treatments (N = 5 mice/group).
