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(A) DiFi colorectal cancer cells treated with cetuximab alone. (B) DiFi cells that stably overexpress heregulin (DiFi-HRG cells) are resistant to cetuximab as a result of HER2-HER3 heterodimerization and AKT activation induced by heregulin. (C) Patritumab abrogates cetuximab resistance mediated by the heregulin autocrine loop in DiFi-HRG cells.
